TUBERCULOSIS MEDICATION
DRUG AND FOOD INTERACTIONS

Multiple significan interactions occur between TB medications
and other medications. The absorption of many TB drugs
is adversely affected by food and some medications

Consultation to healthcare providers at 1-800-TEX-LUNG
2303 S.E. Military Drive, San Antonio,TX 78223

www.HeartlandNTBC.org

Excellence, Expertise, Innovation.
Revised 12-31-10.

INH DRUG INTERACTIONS
Hypoglycemics, Monitor glucose, may cause hyperglycemia.
Tylenol, hepatotoxicity.
Anticoagulants, anticoagulant effect.
Valium (& others), valium toxicity.
Carbamazepines, toxicity of both.
Disulfiram (Antabuse), Psychotic episodes.
Haldol, haldol toxicity.
Ketoconazole, ketoconazole effect.
Dilantin, dilantin toxicity.
Theophyllin, theophyllin toxicity.
Valproate, hepatic and CNS toxicity.

Anticoagulants decrease anticoagulants effect antidepressant
Antidepressants decrease effect
Beta-Blockers decrease beta blockade
Contraceptives decrease contraceptive effect
Corticosteroids Marked decrease steroid effect
Cyclosporine decrease cyclosporine effect, increase Rifampin
Protease Inhibitors Marked decrease activity of PI, increase Rifampin.
Delavirdine Marked decrease delavirdine effect
Efavirenz Slight decrease efavirenz effect, decrease Rifampin
Digoxin decrease digoxin effect
Diltiazem decrease diltiazem effect
Fluconazole decrease fluconazole effect
Itraconazole decrease itraconazole effect
Haloperidol decrease haloperidal effect
Methadone decrease methadone effect
Dilantin decrease dilantin effect
Verapamil decrease verapamil effect
Tetracyclines decrease tetracycline effect
Trimethoprim-Sulfa decrease Possible Rifampin toxicity
Chloramphenicol decrease chloramphenicol effect

Produced by Heartland National TB Center.
Consultation to healthcare providers at 1-800-TEX-LUNG, www.HeartlandNTBC.org
This product produced with funds awarded by the Centers for Disease Control & Prevention (CDC).

FOOD/DRUGINTERACTIONS
INH: Take 1 hour before or 2 hours aftermeals. May take with small snack if needed. Take 1 hour
before or 2 hours after antacids. Avoid alcohol. Supplement Vitamin B6 as needed (25-50mg).

Rifampin: Take 1 hour before or 2 hours aftermeals. May take with small snack if needed.
Take 1 hour before antacids. Avoid alcohol.

Ethambutol: Maybe taken with food.

Moxifloxacin/Levofloxin: Take 2 hours before or after aluminum magnesium or calcium containing
antacids, iron, vitamins, sucralfate, milk containing products and food supplements.

PZA: May be taken with food.

Ethionamide: Take with or after meals. Avoid alcohol. Supplement Vitamin B6 50-100 mg daily. Avoid alcohol.

Amikacin: Increase fluid intake. May be taken on a full or empty stomach.

Streptomycin: May affect the taste of food. Increase fluid intake.

Capreomycin: May need to increase in take of foods high in potassium, but assure normal renal
function first. Increase fluid intake. May be taken on a full or empty stomach.

Para-Aminosalicylic Acid(PAS): Take with or immediately following meals. Increase fluid intake.

Cycloserine:Supplement Vitamin B6 as directed. Avoid alcohol.

Linezolid: May be taken with food. Supplement Vit. B6 100mg daily. Avoid food and drinks that
contain tyramine. Do not use with drugs that promote release of serotonin or block its uptake
(serotoninsyndrome).