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Table 7. First-line TB Drugs in Special Situations1, 2000

Drug CNS TB Disease Renal Insufficiency
Isoniazid Good penetration Normal clearance
Rifampin Fair penetration of inflamed meninges (10%-20%) Normal clearance
Pyrazinamide Good penetration Clearance reduced
Decrease dose or prolong interval
Ethambutol Penetrates inflamed meninges (4% - 64%) Clearance reduced
Decrease dose or prolong interval
Streptomycin Fair penetration of inflamed meninges Clearance reduced
Avoid in end-stage renal disease

Footnotes

CNS = central nervous system

  1. Consult product insert for detailed information

 


Released October 2008
Centers for Disease Control and Prevention
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